Leukemoid reaction is a response of the hematopoietic system to stimulation, characterized by a significant increase in peripheral blood leukocytes and the appearance of immature cells, resembling leukemia.

bubble_chart Auxiliary Examination

1. Blood picture: Red blood cells and hemoglobin may be normal (except in cases of acute hemolysis, massive blood loss, and leukemia), and platelet count is normal. The white blood cell count is significantly elevated >25×10⁹/L, with the highest reaching 200×10⁹/L. Depending on the different stimulating factors on the body, there are various types of leukemoid reactions, which may manifest as an increase in the proportion of granulocytes, monocytes, lymphocytes, or eosinophils. Immature cells may be observed in the differential count, and toxic granules and vacuoles often appear in the cytoplasm of neutrophils.
2. Bone marrow picture: The marrow is hyperactive or markedly hyperactive, with no significant increase in blast cells and no morphological abnormalities characteristic of leukemia. The erythroid and megakaryocytic series are normal.
3. Cytochemical staining: The neutrophil alkaline phosphatase score is significantly increased.
4. Genetic testing: No Ph1 chromosome is present.

bubble_chart Diagnosis

1. Medical History and Symptoms

1. Medical History Inquiry: Note:
2. Whether there is infection by bacteria, fungi, or Chinese Taxillus Herb parasites.
3. Whether the patient suffers from autoimmune diseases (rheumatoid arthritis, sarcoidosis, etc.) or neoplastic diseases (renal tumors, leukemia, etc.).
4. Whether medications such as glucocorticoids, adrenaline, or lithium chloride have been used.
5. Whether there is severe burns, crush injuries, electric injury; poisoning; acute hemolysis or massive blood loss; whether the patient is in the bone marrow suppression stage of convalescence, etc.
6. Clinical Symptoms: Depending on the primary disease, corresponding clinical symptoms may appear.

2. Physical Examination Findings:

Mainly the corresponding signs of the primary disease.

bubble_chart Treatment Measures

Leukemoid reaction itself does not require treatment and can resolve rapidly once the underlying disease cause is removed. Therefore, the primary disease should be carefully identified and actively treated.

bubble_chart Differentiation

Leukemoid reactions often have clear triggers, but when the primary disease is more concealed, differentiation from leukemia should be considered.