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Yibian
 Shen Yaozi 
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formula nameMajor Purgative Decoction
sourceTreatise on Cold Damage and Miscellaneous Diseases
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bubble_chart Preparation and Dosage

Rhubarb Rhizoma (Radix et Rhizoma Rhei) washed with wine 12gm (4 liǎng)
Magnolia Bark (Cortex Magnoliae Officinalis) peeled, roasted 15gm (8 liǎng)
Immature Orange Fruit (Fructus Aurantii Immaturus) roasted 12gm (5 pieces)
Mirabilite (Natrii Sulfas) 9gm (3 hours)

Take the above four ingredients, boil Magnolia Bark and Immature Orange Fruit in 1 liter of water first, then reduce to 500 milliliters and remove the residue. Add Rhubarb Rhizoma and continue boiling until reduced to 200 milliliters, then remove the residue. Add Mirabilite and simmer gently for one or two boils. Divide and take warm in two doses. If a bowel movement occurs, stop taking the remaining dose.

bubble_chart Efficacy

Clearing heat and purging the lower.

bubble_chart Indications

  1. Yang brightness fu-organ syndrome/pattern, epigastric and abdominal stuffiness and fullness, abdominal pain with guarding, hard upon palpation, constipation with frequent passage of flatus, or even tidal fever and delirious speech, sweating on hands and feet, tongue coating yellow and thick, dry and prickly, or charred and dry with cracks, pulse deep and replete.
  2. Heat retention with watery discharge, diarrhea with clear water, exceptionally foul odor, pain around the navel and abdomen, palpable masses, dry mouth and tongue, pulse slippery and rapid.
  3. Interior heat excess syndrome/pattern of heat reversal, convulsive disease or mania, etc., belonging to interior excess heat syndrome/pattern.

bubble_chart Formula Principles

In the formula, Immature Orange Fruit relieves stuffiness and breaks up stagnation; Magnolia Bark eliminates fullness and moves qi; Mirabilite moistens dryness and softens hardness; Rhubarb Rhizoma attacks excess and purges downward. When Mirabilite and Rhubarb are used together, they synergistically clear heat and eliminate accumulation, promoting the expulsion of the old and the generation of the new. Immature Orange Fruit and Magnolia Bark used together also regulate and harmonize gastrointestinal function. The combination of these four ingredients ensures that blockages are cleared, obstructions are relieved, and foul qi is eliminated. This formula is commonly used for cold purgation.

bubble_chart Syndrome Differentiation

  1. Yang brightness fu-organ syndrome/pattern.
  2. Abdominal distension and fullness, pain, and hardness.
  3. Constipation or diarrhea with clear water.
  4. Tongue with dry, yellow, and thick coating.
  5. Deep and solid or slippery and rapid pulse.

bubble_chart Formula Modification

  1. dryness-heat and thirst: add Gypsum, Anemarrhena.
  2. qi stagnation and blood stasis: add Red Peony Root, Peach Kernel.
  3. abdominal distension and fullness: add radish seed, Aucklandia Root.
  4. high fever and convulsions: add Acorus, Uncaria.
  5. profuse sweating: add Fossil Bone, oyster shell.
  6. jaundice: add Virgate Wormwood, Phelloendron Bark, Skullcap Root, Gardenia.

bubble_chart Cautions and Contraindications

Use with caution in cases of non-Yangming excess heat syndrome/pattern.

bubble_chart Modern Application

Intestinal obstruction, acute pancreatitis, acute cholecystitis, acute infectious hepatitis, appendicitis, apoplexy, shock, biliary tract infection, tetanus, hypertension, constipation, food poisoning, measles, urticaria, infantile acute convulsion, epilepsy, schizophrenia, obesity, eye diseases, puerperal fever, dysentery, epidemic dysentery, fatty heart, etc.

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