Currently, this disease is considered a variant of localized neurodermatitis, clinically characterized primarily by verrucous nodules accompanied by intense itching. The cause of the disease remains unclear and may be related to insect bites, gastrointestinal dysfunction, and endocrine disorders.

bubble_chart Clinical Manifestations

1. It is more common in adult women, with skin lesions predominantly occurring on the limbs but also seen on the waist and buttocks, most frequently on the extensor surfaces of the lower legs;
2. Initially, the skin lesions appear as light red papules, which later develop into hemispherical, firm nodules the size of soybeans to broad beans. The surface is rough and verrucous, appearing reddish-brown or grayish-brown, and may show scratch marks and blood crusts. The number of lesions varies, and they exist in isolation;
3. The course is chronic, persisting for years without resolution, and is accompanied by intense itching.

bubble_chart Diagnosis

1. It commonly occurs in adult women, predominantly on the limbs, especially the extensor surfaces of the lower legs;
2. The typical skin lesions are hemispherical, firm, verrucous nodules, ranging from the size of a soybean to a broad bean, and appear isolated;
3. The course is chronic, with intense itching.

bubble_chart Treatment Measures

Principles of Treatment

1. Prevent and manage various inducing factors such as insect bites;
2. Administer oral antihistamines and sedative-hypnotic drugs;
3. In severe cases, medications such as ethambutol, thalidomide, Root Leaf or Flower of Common Threewingnut, and corticosteroids may be used;
4. Topical application of corticosteroid ointment with occlusive dressing or plaster, or local block therapy and cryotherapy may also be employed.

1. Generally, 1-2 types of oral antihistamines and sedative-hypnotic drugs are prescribed, along with topical corticosteroid ointment with occlusive dressing or plaster, or local block therapy and cryotherapy;
2. In severe cases, medications such as ethambutol, thalidomide, Root Leaf or Flower of Common Threewingnut, and corticosteroids may be used.

bubble_chart Cure Criteria

1. Cured: Rash subsides, cutaneous pruritus disappears;
2. Improved: Rash decreases, cutaneous pruritus alleviates;
3. No cure: Skin lesions remain unchanged.