Vaginal intraepithelial neoplasia includes atypical hyperplasia of the vaginal epithelium and carcinoma in situ.

bubble_chart Diagnosis

1. There are often no obvious clinical manifestations, occasionally with bloody leucorrhea after intercourse or very slight bleeding. No obvious lesions are visible to the naked eye during vaginal examination.
2. Abnormal cells can be detected in vaginal smears.
3. Colposcopy may reveal white epithelium accompanied by punctate blood vessels, mosaic vascular networks, and other structures.
4. Biopsy is performed under iodine test guidance to confirm the diagnosis.

bubble_chart Treatment Measures

Treatment

1. Local treatment can be performed using laser, cryotherapy, or electrocoagulation. 2. Apply 5% 5-fluorouracil cream topically once daily for 5 applications as one treatment course, and observe for 6–12 weeks. 3. Surgery: The extent of surgery is determined by the scope of the lesion. For small tumors, local excision or partial vagina resection may be performed. For extensive lesions, total vagina resection or total uterus and vagina resection may be required. For young patients, seasonal epidemic vagina reconstruction should be considered. 4. For elderly and frail patients who cannot tolerate surgery or whose uterus has already been removed, and for cases where the extent of lesions in the vaginal vault is difficult to accurately assess and conservative treatment is ineffective, vaginal radiotherapy (brachytherapy) may be performed.