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Yibian
 Shen Yaozi 
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formulaCold-Limbs Powder Si Ni San
sourceShanghan Zabing Lun
smart_toy
bubble_chart Preparation and Dosage

Bupleurum (Radix Bupleuri) 30gm
Immature Orange Fruit (Fructus Aurantii Immaturus) 30gm
Peony Root (Radix Paeoniae Alba) 30gm
Liquorice Root (Radix Glycyrrhizae) 30gm

bubble_chart Efficacy

Relieving depression and heat, soothing the liver and regulating the spleen.

bubble_chart Indications

Pattern of true heat with false cold, although there is reversal cold of the hands and feet, there is also body heat or epigastric and abdominal pain, or diarrhea with tenesmus, or difficulty in urination, and a wiry pulse.

bubble_chart Formula Principles

In the formula, Bupleurum soothes the liver and relieves depression, penetrating and dispersing stagnant heat as the sovereign; Immature Orange Fruit drains heat and dissipates nodules, used together with Bupleurum, one ascending and the other descending, together achieving the effect of ascending lucidity and descending turbidity as the minister; Peony Root emolliates the liver and astringes yin as the assistant; Prepared Liquorice Root tonifies the spleen and harmonizes the middle, tonifying qi as the envoy. The combination of Peony and Liquorice regulates and harmonizes the liver and spleen, alleviating urgency and pain. It is widely used in clinical applications and is a fundamental formula for treating liver-spleen qi stagnation.

bubble_chart Pattern Identification

  1. Reversal cold of limbs (yang pathogen).
  2. Fever.
  3. Pain in the hypochondrium and abdomen.
  4. Diarrhea with tenesmus.
  5. String-like pulse.

bubble_chart Formula Modification

  1. Flank pain: Add Cyperus, Curcuma Root, Corydalis Tuber.
  2. Liver-stomach disharmony, qi stagnation, and blood stasis: Add Cyperus, Sichuan Lovage Rhizome.
  3. High blood pressure: Add Hematite, Fossil Bone, oyster shell, Skullcap Root.
  4. Scanty urine: Add Akebia Stem, Unprocessed Rehmannia Root.
  5. Liver and gallbladder diseases: Add Virgate Wormwood, Christina Loosestrife, Curcuma Root, Salvia. Or combine with Powder of Capillaris and Five Ingredients with Poria.
  6. Severe constipation: Add Rhubarb Rhizoma, Mirabilite.
  7. Vomiting: Add Coptis Rhizome, Fresh Ginger Rhizome, Cardamon Fruit.
  8. Spleen deficiency anorexia: Add Tangshen, White Atractylodes Rhizome.

bubble_chart Cautions and Contraindications

This formula is contraindicated for those with spleen-kidney yang deficiency or yin pathogen reversal cold of the limbs.

bubble_chart Modern Application

This formula regulates the functions of the liver, gallbladder, spleen, and stomach to achieve harmony. It is used for chronic hepatitis, pancreatitis, cholecystitis, chronic gastritis, gallstones, intercostal neuralgia, colitis, gastrointestinal neurosis, pelvic inflammation, menstrual irregularities, gastrointestinal ulcers, and hypertension.

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