Lu Zhi-yi (circa 1598–1664) was a medical scholar during the Ming and Qing dynasties. His courtesy names were Ziyou, Yousheng, and Ziying, and his pseudonyms were Jingong and Luzhongren. He was from Qiantang (present-day Hangzhou, Zhejiang Province) and was the son of the renowned physician Lu Fu. Zhiyi inherited his family's medical knowledge from a young age and was skilled in prescribing medications by his youth. Initially, his father instructed him to write a commentary on the *Jingui Yaolue*, but he burned the draft due to its immaturity, vowing to write again after ten years. He approached medical diagnosis with meticulous care, often successfully treating rare and complex illnesses, sometimes with immediate results, earning admiration from his peers. Due to setbacks in his official career, he devoted himself to the study of medical theory and focused on writing. He spent eighteen years compiling *Materia Medica Chenya*, which included 355 medicinal substances. For each substance, he used the Buddhist concept of "fourfold multiplication" to explain it in four sections, namely "[Xi^□] Can Yan Duan." Unfortunately, the book was destroyed by fire during wartime. Later, he reconstructed it from memory, but only half of the original content was restored, and it was published as *Materia Medica Chenya Banji*. Lu deeply studied the *Book of Changes* and integrated its principles with medical theory. He authored numerous works, including the four-volume *Xue Gu Zhen Ze*, *Zhongjing Shanghan Lun Shu Chao Jinbi*, *Mosuo Jingui*, and *Xiayin Qupi*. He also wrote *Malaria Lun Shu*, which provided significant insights into the *Nue Lun* of the *Neijing*. Later, due to overwork, he gradually lost his eyesight.