Zheng Shou-quan, styled Qin'an, was a renowned scholar of cold-damage disease in the late Qing Dynasty, born in Guyi Town, Qiongzhou, Sichuan (now Guyi Town, Qionglai, Chengdu) in the fourth year of the Daoguang era (1824) and passed away in the third year of the Xuantong era (1911) at the age of 87. He studied medicine under the tutelage of the erudite scholar and famous physician Liu Zhitang (author of "Constant Interpretation of the Thirteen Classics" and dozens of other works on philosophy, history, and poetry), who taught him to thoroughly read and deeply contemplate the Neijing, the "Book of Changes," and texts on cold-damage disease. Zheng devoted over twenty years to exploring the essence of these three texts, ultimately understanding the principle of the unity of yin and yang in the human body and the significance of Zhang Zhongjing's establishment of medical principles and prescriptions. Thus, the foundation of his academic thought traces back to the "Book of Changes" and the Neijing, incorporates the core teachings of cold-damage disease, and draws on the strengths of medical writings from various dynasties. Consequently, his mastery of medical theory and practice reached an exceptional level. He authored three influential books: "True Transmission of Medical Principles," "Comprehensive Medical Methods," and "Constant Discussion on Cold-Damage Disease." This paper provides a preliminary exploration of his contributions to the development of Zhang Zhongjing's academic legacy.