Wu Zhen, courtesy name Kun'an, was a renowned physician during the Qianlong and Jiaqing eras, hailing from Wuxing (present-day Huzhou City). He closely associated with Ye Tianshi and Xue Shengbai of Wuzhong, delving deeply into the secrets of treating "cold-damage disease," and thus made significant contributions to the diagnosis and treatment of seasonal febrile diseases. Based on his synthesis of his mentors' experiences and his own clinical insights, he advocated for dividing febrile diseases into two main categories: true cold-damage disease and cold-damage-like disease, asserting that the latter accounted for eighty to ninety percent of cases. He emphasized that Zhang Zhongjing's 113 formulas were designed to correct errors, particularly proposing the "ancient methods" and "new methods" for rescuing patients from critical conditions, offering many innovative ideas in the treatment of febrile diseases. He authored the four-volume "Cold-Damage Disease Guide" (later annotated by He Lianchen and renamed "The Precious Raft of Febrile Diseases"), which meticulously details diagnosis, the treatment of cold-damage disease, and rescue methods, making him a key figure in introducing Wu culture to the field of medicine.