Zhu Wei-ju (1884–1951), also known as Aoshuang Xuanzhu, was from Shaoxing, Zhejiang. His ancestors were generations of medical practitioners. Later, Zhu enrolled in a military medical school, studied for two years, and then followed his teacher Shitian to Japan. The following year, he returned to Sichuan and worked at the Chengdu Official Hospital, moving to Shanghai in 1917. He once taught at the Shanghai Chinese Medical College and later served as the director of the Shanghai New National Chinese Medicine Research Institute. Zhu emphasized yang qi in treating diseases, believing that a decline in yang qi leads to disease progression, while an increase in yang qi drives away pathogenic factors. He was known for his frequent use of warming and heat-inducing formulas, particularly Aconite Lateral Root, earning him the nickname "Zhu Aconite Lateral Root." Zhu was well-versed in both Chinese and Western medicine, and his academic work was highly innovative. His views on the pathology of cold-damage disease, as well as his perspectives on pathogenic factors, healthy qi, and yin-yang, differed significantly from those of other physicians of his time. In 1944, he engaged in scholarly debates with his disciple Chen Susheng, culminating in the publication of Cold-Damage Disease Inquiry, a six-volume work.