Compiled by Tao Hongjing of the Liang Dynasty, in seven volumes. The original book is lost, but its contents are still scattered in the Jingshi Zhenglei Beiji Bencao. This book is based on the contents of Shennong Bencao Jing and Mingyi Bielu, each containing 365 types, totaling 730 types, and is divided into six categories: jade and stone, grass, wood, fruit, vegetable, and those with names but not yet used. It is also a significant achievement in the history of materia medica development during this period. Bencao Jing Jizhu exists in two fragments: one unearthed from the Dunhuang Grottoes and the other from Turpan.

The Dunhuang fragment only survives in one volume, which is the "Preface" section. The original scroll was seventeen meters long, with writing on both sides. In 1908, Japanese explorers Tachibana Zuicho and Yoshikawa Koichiro, under the orders of Otani Kozui, carried it from Dunhuang to Japan during their expedition in Central Asia. The front and a small part of the back of this scroll contain other documents, while the back has 720 lines belonging to the preface of Bencao Jing Jizhu, but the beginning of the scroll is missing. According to the last two lines of the text, which read, "On the 11th day of the ninth month of the Kaiyuan era, Yuchi Lulin wrote a volume of materia medica in the capital. Recorded at the hour of Chen," Luo Zhenyu believed that this text, differing in calligraphy from the original, should be a work from the Six Dynasties period. This fragment was reprinted by Qunlian Publishing House in 1955.

The fragment unearthed in Turpan is a damaged piece measuring 28.5 x 27 cm. The scroll contains only the complete text regarding swallow droppings and bat droppings, the latter half of the commentary on pig testes, as well as the beginning of the main text on mole crickets (or mole rats). It appears to be a partial section on animal-based medicines from the Bencao Jing Jizhu.