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This book was compiled by Ye's disciples, including Hua Diyun, who collected Ye's medical cases. The book consists of 10 volumes, divided into 89 categories according to diseases. Volumes 1 to 8 cover internal medicine, Volume 9 covers gynecology, and Volume 10 covers pediatrics. Each category is followed by the author's general comments, summarizing the key points of the disease, diagnosis, and treatment methods, with additional annotations by Xu Ling-tai, which are very enlightening for studying Ye's cases.

This book is a record-style case history, with detailed and accurate records of the conditions, including names, ages, symptoms, pulse manifestations, prescriptions, and dosages, accompanied by brief explanations of the disease mechanisms. It realistically reflects the original diagnostic and treatment practices of the physician. Some cases first describe the symptoms, then analyze the causes and mechanisms, followed by diagnosis and treatment; others combine symptoms, causes, mechanisms, and treatment methods, interspersed with commentary. The categories are arranged according to the diseases. Ye is known for his light and simple use of medication, often using six-ingredient formulas, followed by eight-ingredient ones. Statistics show that six-ingredient formulas account for 40.27% of the book, totaling 1209 formulas; eight-ingredient formulas account for 18.65%, totaling 506 formulas; ten-ingredient and above formulas only account for 5.76%, with only 174 formulas. The fewest ingredients used in a formula is one, and the most is one formula with 21 ingredients.

The order of cases discussed in each volume is as follows. Volume 1: apoplexy, liver wind, vertigo, recurrent headache, deficiency fatigue; Volume 2: cough, hematemesis, loss of voice, lung atrophy; Volume 3: seminal emission, turbidity, impotence, sweating, collapse, spleen and stomach, wood overacting on earth, swelling; Volume 4: abdominal mass, stuffiness, dysphagia, regurgitation, belching, vomiting, vomiting of roundworms, loss of appetite, intestinal obstruction, constipation, lung atrophy, chest obstruction, wheezing, asthma, hiccups, jaundice; Volume 5: wind, cold, wind-dampness, damp-heat, summerheat, dampness, dryness, epidemic, sand rash, phlegm, phlegm-fluid retention; Volume 6: depression, liver fire, insomnia, triple wasting, spleen heat disease, malaria, diarrhea; Volume 7: dysentery, bloody stool, rectal prolapse, atrophy, impediment, convulsive syncope, fright, epilepsy; Volume 8: nosebleed, hernia, headache, heart pain, epigastric pain, hypochondriac pain, abdominal pain, shoulder, arm, and back pain, waist, leg, and foot pain, various pains, ear, eye, nose, tooth, throat, sores and ulcers; Volume 9: regulating menstruation, vaginal discharge, menorrhagia and metrostaxis, prenatal, postpartum, masses, heat entering the uterus; Volume 10: pediatric essentials, sand rash, smallpox, malnutrition, vomiting and diarrhea, convulsions, syncope, worms. Appendix: collection of formulas.

Ye was a famous physician in the early Qing dynasty, who established the warm disease Weiqi nutrient-blood pattern identification and treatment theory system. A master in treating miscellaneous diseases, he drew from various strengths, learned from the ancients without being constrained by them, and was renowned in the medical community for his accurate diagnosis, ingenious treatment methods, and flexible use of medication. Linzheng Zhinan Yi'an preserves a large amount of Ye's original diagnostic and treatment data, serving as an important resource for later generations to explore his academic thoughts. It further elaborates on the theory of warm diseases; many clinical physicians have studied this book to learn Ye's academic strengths. Thus, this book has gained exceptional reputation within the medical community.

Existing major versions include: the 1764 Qing Dynasty Qianlong 29th year edition (with "Zhongfutang Gongxuan Liangfang"); the 1766 Qing Dynasty Qianlong 31st year edition from Chongde Academy; the 1885 Qing Dynasty Guangxu 11th year edition from Saoye Shanfang; the 1892 Qing Dynasty Guangxu 18th year edition from Shanghai Tushu Jicheng Yinshuju; the 1919 Shanghai Wenyi Shuju lithographic edition with Xu's annotations; and the 1928 Shanghai Jinwentang Shuju lithographic edition.