6 volumes, written by Yang Xuan (Chestnut Mountain) of the Qing Dynasty, published in the 49th year of Qianlong (1784). Yang , recognizing the ease of confusion between cold-damage disease and pestilence, compiled and detailedly distinguished various scholarly theories. Volume one lists and describes the pulse signs, causes, and treatments of cold-damage disease and pestilence; volumes two and three detail the characteristics of various symptoms of cold-damage disease, pestilence, and warm disease; volumes four and five are "Medical Prescriptions Differentiation," listing 180 main prescriptions and 34 supplementary prescriptions; volume six is "Materia Medica Differentiation," introducing 188 commonly used drugs for cold-damage disease and pestilence. The basic content of this book is extracted and expanded from Wu You-ke's "Wenyi Lun," Chen Yaodao's "Differentiation of Cold-Damage Disease," and other books, and it innovatively uses famous prescriptions for treating pestilence such as Powder for Ascending and Descending. The Powder for Ascending and Descending is composed of Stiff Silkworm (fried with wine), cicada slough, Turmeric (peeled), and raw Rhubarb Rhizoma, taken with honey and yellow wine. It is mainly used to treat pestilence and warm disease with symptoms of internal and external, triple energizer great heat, whose symptoms are indescribable. The so-called "ascending and descending" refers to the "raising the clear and lowering the turbid" against warm and pestilent pathogens, to expel evil and detoxify. This prescription has been widely used by later physicians. The original edition and various other editions and printed versions are extant.