This book was written by Yu Tuan and completed in the year 1515 (Zhengde Yihai). It is based on the essential principles of Suwen and Nan Jing, incorporating various scholarly theories, extensively collecting and compiling, and integrating the author's own insights. It was published in 1531 (Jiajing Xinmao). There were reprints in 1577 and 1578 (Wanli 5th and 6th years), and a lithographic edition by Huiwentang in modern times. In Japan, editions were published in 1604, 1622, and 1659. The People's Medical Publishing House printed it twice in 1965 and 1981.

The book consists of 8 volumes. Volume 1 begins with "51 Questions on Medicine," discussing the origins and transmission of medical knowledge, the concept of "Kang Hai Cheng Zhi," DanxiYishuo, and comprehensive analysis of four examinations, offering insightful perspectives. Following the "Questions," it details nearly a hundred diseases categorized into internal, external, gynecological, and pediatric sections, including over a thousand prescriptions. The general discussions on diseases are drawn from the essential principles of Neijing, pulse methods from Wang Shu-he, cold-damage disease from Zhang Zhong-jing, internal injuries from Li Dong-yuan, and pediatrics from Qian Yi. Other diseases primarily follow Danxi, with selected prescriptions from Liu Hejian, Zhang Yuqi, Li Dong-yuan, and others, including family traditions and personally tested effective prescriptions appended. This book serves as a comprehensive clinical reference and has had a certain influence on later generations.