The northern part of the mainland is mainly taken from the japanese buttercup herb family plant Northern Aconite Mother Root (Aconitun Kusnezoffii Reochb.), while the southern part is mainly taken from the roots of the Aconite Mother Root. The kusnezoff monkshood root used in the market are all wild products and are distributed in Heilongjiang, Jilin, Liaoning, Hebei, Shanxi, Inner Mongolia and other provinces.

Kusnezoff monkshood root, as it has been called in the past, is mainly a wild species of Aconite Mother Root. According to its origin, it is mainly a wild species of Aconite Mother Root (Aconitum carmichaeli Debx.), Li Shi -zhen The so-called Huai Aconite Mother Root that was born in Jiangbei; in addition, it also includes the Northern Aconite Mother Root.

The root tuber is conical, about 1.5-5cm long and 1.5-3.5cm in diameter. The surface is grey-brown, with fine longitudinal wrinkles. There are concave bud marks on the upper end, and there are multiple knob-like raised roots around it, commonly known as "nail horns". There are traces of being removed from the mother root on the side. It is solid and has a gray-white cross-section. It is powdery, with 5 to 7 angular or irregular cambial rings visible on the cross section. It tastes spicy and numbs the tongue.

Heishun slices are longitudinally sliced, wide at the top and narrow at the bottom, 4 to 5 cm long, 1 to 3.5 cm wide, and about 3 to 5 mm thick. The outer skin is dark brown or gray brown, and the cut surface is brown and translucent. There are longitudinal duct bundles. Hard and brittle. The smell is slight and the taste is light.

extremely hot, acrid and bitter, extremely toxic. act on heart, liver, kidney and spleen channels.

[Efficacy]

Restoring yang to save from collapse, tonifying fire and assisting yang, dispelling wind, dehumidification, warming meridian and dissipating cold, pain relief.

[Indications]

Used for yang exhaustion, cold limbs and weak pulse, impotence, uterine cold, vomiting and diarrhea due to deficiency and cold, pudendal coldness edema, yang deficiency external contraction, wind-cold-dampness impediment, limb joint cold pain or numbness paralysis, confidant cold pain, cold abdominal colic pain, traumatic pain, anesthetic and analgesic effects. External treatment of Yongju scabies.

Processing of materia medica: 1.4~4.5g. It should be decocted first and fried for a long time. For external use, apply an appropriate amount to the affected area or decoct it with water and wash it off. Caution should be exercised when taking raw products orally, generally after processing of materia medica.

[Precaution]

Pregnant women should not take this product. Anti-Pineilia, Trichosanthis Fruit, Japanese ampelopsis root, common bletilla pseudobulb, Tendrilleaf Fritillary Bulb, Thunberg Fritillary Bulb; fear of Rhinoceros Horn. It should not be taken for a long time. The raw product is for external use only.

[Modern Pharmacology]

The raw product contains the highly toxic diester alkaloids Aconite Mother Root alkali (aconitine), meso Aconite Mother Root alkali (mesaconitine) and hypo Aconite Mother Root alkali (hypaconitine), as well as the cardiotonic norlindera alkali (higenamine). ) and coryneine chloride, common russianthistle herb Lindera base (salsolinol), which have a pressor effect.

• kusnezoff monkshood root crude drug preparation, Aconite Mother Root base, sub-Aconite Mother Root base all have analgesic effect on the pain response caused by electrical stimulation of rat tail method or hot plate method, Aconite Mother Root total alkaloids It has anti-inflammatory effects on rabbit ear swelling caused by heat and experimental abdominal membrane inflammation in mice. Clinically, kusnezoff monkshood root is made into an injection containing 2 mg of total alkaloids per 2 ml, which can be injected intramuscularly or used in combination with other medicinals to treat wind-dampness arthritis, low back and leg pain, neuralgia, etc.
• Aconite Mother Root alkali stimulates the sensory nerve endings of the skin mucosa membrane, causing itching and heat sensations, and then inhibits them to produce a local anesthetic effect. Clinically, the raw kusnezoff monkshood root is used together with other medicines to make a tincture for topical anesthesia; or the raw medicine is mixed into a plaster for external use, which has anesthetic and analgesic effects.
• Kusnezoff monkshood root has cardiotonic effects similar to Aconite Lateral Root.
• Raw materials without processing of materia medica are very toxic. People often experience toxicity when taking more than 0.3g. Therefore, they are generally not taken orally. Those who take them internally are processed of materia medica. The toxicity to mice after processing of materia medica can be significantly reduced. For example, the 50% lethal dose (intraperitoneal injection) of Aconite Mother Root to mice for raw use is 0.19g/kg, while after processing of materia medica it is 6~ 10g/kg.

• Nervous system: numbness and tightness in the mouth, tongue, limbs and body, dysphoria, restlessness, dizziness, headache, confusion; disappearance or weakening of pain, paroxysmal convulsion; or blindness .
• Digestive system: severe vomiting, nausea, salivation, abdominal pain, diarrhea, and hyperactive bowel.
• Circulatory system: flustered ness palpitation, decreased blood pressure, arrhythmia, even cyanosis, cold limbs. Severe arrhythmia or circulatory and respiratory failure are the main causes of death.

• Early gastric lavage.
• Intravenous infusion of glucose injection and glucose saline. Pay attention to insulation and breathing.
• Use the antagonist atropine until the heart rhythm returns to normal.
• The folk prescription uses 15g each of Fresh Ginger Rhizome and Liquorice Root, and 18g Lonicera, decoction and taken. Or take 120g of Mung Bean and 30g of Liquorice Root in decoction and take frequently. Raw white honey also has a certain toxin-removing effect.