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Yibian
 Shen Yaozi 
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drug nameToad Venom
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[Variety Source]

This product is a white serous fluid secreted by the postauricular glands and skin glands of the Bufo family Bufo (Bufo gargarizans Cantor) or Black-orbited Toad (Bufo melanostictus Schneider). Processed and dried. It is distributed in most parts of the country, mainly produced in Hebei, Shandong, Sichuan, Hunan, Jiangsu, Zhejiang and other places. It is mostly caught in summer and autumn. After catching the toad, wash and dry the body surface, squeeze out the white slurry from the post-auricular gland and skin gland, and put it in a porcelain vessel (avoid contact with ironware, otherwise it will easily turn black) Immediately filter out the soil and impurities with a copper sieve, apply it on glass plates, bamboo chips, or scrape it into a circular mold, dry it in the sun and store it. When used, dissolve the broken pieces in wine or fresh milk, then air-dry or sun-dry, grind into fine pieces, and form into pills or powders.

[Property]

Acrid, warm. toxic. act on heart channel.

[Efficacy]

resuscitation: refreshing, relieving pain, removing toxin.

[Indications]

  1. Used for filthy-attack eruptive disease abdominal pain, vomiting and diarrhea, and unconsciousness. Toad Venom is pungent and warm, and has the power to wake up and ward off filth, so it can cure summerheat damage, filthy turbidity, filthy-attack eruptive disease caused by unhealthy qi and unclean diet, abdominal pain, persistent vomiting and diarrhea, and even syncope. The syndrome is often combined with medicinals such as musk, Clove, Atractylodes Rhizome, such as Toad Venom Pill.
  2. Used for malignant sores, scrofula, sore throat and various toothaches. This product is poisonous and has a good effect of attacking poison, subduing swelling and relieving pain. It is effective for both external use and oral administration. It is used to treat malignant sores, Yongju boil and sore sores, etc., and is used in combination with Realgar, dry vitriol, Cinnabar, etc. medicinals, in the form of pills Mung Bean, five pills per serving, Fistular Onion Stalk decoction, very effective, such as Waike Zhengzong Toad Venom Pill. To treat scarlatina, throat wind, tonsillitis and sore throat, it is often used in combination with medicinals such as Cow-Bezoar, Realgar, borneol, etc. Such as six gods and nine.
  3. In recent years, Toad Venom has been used to treat various cancers, and it has certain anti-cancer and subduing swelling to relieve pain effects. For example, it can be used to treat liver cancer, intestinal cancer, leukemia, skin cancer, etc. It can be taken internally or externally and has achieved certain curative effects. It is also used clinically for respiratory and circulatory failure. It has a rapid and lasting boosting effect and has a significant exciting respiratory effect.

[Documentation]

  1. Yaoxing Lun: "Take eyebrow fat on the Dragon Boat Festival, take Cinnabar and musk into pills as big as pockmarks, to treat infantile malnutrition and thinness, take one pill hollow: like brain malnutrition, milk tonic, "It's very wonderful to drop into the nose."
  2. Bencao Huiyan: "Toad Venom is a medicine for treating infantile malnutrition with accumulation, eliminating tympanites, and is a detoxifying medicine. It can resolve all stagnant and stagnant diseases. , such as accumulation of poison, accumulation of pus, internal treatment of carbuncle and swollen syndrome, has the effect of attacking poison."
  3. Bencao Biandu: "Good resuscitation can ward off evil and search for evil, but all syndrome. /pattern of obstruction is used in emergent formula to open and close it. However, it is always advisable to be cautious when taking medicine. Try putting a small amount on the skin, and it will immediately blister and corrode. You can know its nature after grinding it and smelling it, and you will stop sneezing. Therefore, it is used in sneezing medicine."

[Usage and Dosage]

Take it as pill powder, 0.015~0.03g each time. Appropriate amount for external use.

[Precaution]

This product is toxic, do not overdose if taken internally; do not enter the eyes if used externally. It should not be used by pregnant women.

[Modern Pharmacology]

The main ingredients contained in this product are chemically classified as bufadienolides, which include bufadienin, sinobufodenin, sinobufotalin, bufalin, etc. Sinobufotoxin isolated from the Chinese toad Toad Venom; after acidolysis, Sinobufotoxin, suberic acid and amino acids are produced. In addition, it also contains indole-based alkaline ingredients; such as serotonin, bufotryptamine, etc., as well as bufalin, bufolin, epinephrine, etc. Toad Venom poison has Rehmannia-like cardiotonic effects. Bufalin and Sinobufolin have similar pressor effects and central excitatory respiratory effects to epinephrine. Toad Venom 80% alcohol extract has a topical anesthetic effect, among which Bufalin has the effect of The strongest, equivalent to 90 times that of cocaine; Toad Venom injection has an inhibitory effect on Proteus, Pseudomonas aeruginosa, Tetradococcus, Staphylococcus albus, and catarrhalis; Toad Venom also has an analgesic effect on striated muscle and uterus. It has an stimulating effect on the fallopian tube, and also has the effects of relieving asthma, antitussive, anti-inflammatory, anti-tumor, anti-radiation and increasing white blood cells.

[Supplementary Medication]

toad skin: the skin of toads such as Chinese giant toad or black-rimmed toad. It tastes pungent, is cool in nature, and is slightly poisonous. Function: clearing heat and removing toxin, diuresis and swelling. Suitable for Yongju sores, infantile malnutrition with accumulated abdominal distension and fullness, scrofula tumors and other diseases. Decoct and take 3~6g. Grind into powder and mix into pills, 0.3~0.9g each time. Appropriate amount for external use, grind into powder and apply to the affected area, or apply it to the affected area with fresh toad skin.

It has been reported in recent years that using toad skin to treat chronic bronchitis and malignant tumors, such as stomach cancer, esophageal cancer, liver cancer, breast cancer, lymphatic fleshy tumors, etc., has certain effects.

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