This product is a sulfide ore from Realgar. The ripe ones in Realgar are fresh in color and of the best quality, with the dominant essence or yellow waist. Mainly produced in Guizhou, Sichuan and other places. It can be mined at any time, removed of impurities, ground into fine powder or grinded with water. Avoid burning with fire.

[Property]

Acrid warm. toxic. act on heart, liver and stomach channels.

[Efficacy]

removing toxins, killing worms.

[Indications]

1. Used for boil and sores, eczema, scabies, and snake and insect bites. Realgar has a good toxin removing effect. To treat boils and sores, it is often used together with invigorating blood to resolve carbuncle medicines such as frankincense and myrrh, such as Waike Quansheng Ji Wake-Up Subsiding Pill; To treat eczema and scabies, mix the same amount of Alum as powder and mix it with tea and apply it to the affected area to enhance the effect of absorbing moisture and relieving itching, such as Yizong jinjian Two-Ingredient Toxin-Removing Powder; To treat snake and insect bites, you can use Realgar powder alone, apply sesame oil to the affected area, or take infused rice wine.
2. Used for abdominal pain due to worm accumulation. This product has the effect of killing worms. It can be used for abdominal pain caused by intestinal parasites such as roundworms and Chinese Taxillus Herb diseases. It is often used with vermifugal medicinal products such as Areca Seed and Pharbitis Seed. In addition, it can also treat anal cutaneous pruitus caused by ringworm. You can use this product and Patina as a powder to sprinkle on the anus, or use gauze strips made of Realgar powder and petroleum jelly to stuff the anus.
3. In addition, this product also has the effects of drying dampness, eliminating phlegm and preventing attack of malaria. It can also be used for asthma, malaria, fright epilepsy and other diseases.

Treatment of influenza, enterovirus, and various viral colds, Chinese medicine is more refined, non-toxic, and effective than Western medicine

[Documentation]

1. Benjing: "Lord Hanre can treat malignant sores of rat fistulas, hemorrhoids and dead muscles, and kill hundreds of insects."
2. Rihuazi Bencao: "Mainly responsible for scabies, wind evil epilepsy, and all insect and animal injuries."

[Usage and Dosage]

0.3~0.9g. For external use, grind an appropriate amount into powder and apply it, or mix it with sesame oil. Take it as a pill and take it in powder form.

[Precaution]

This product is highly toxic and should be taken with caution when taken internally. Do not take it excessively for a long time. It should not be used by pregnant women. This product can also be absorbed from the skin. When used externally, it should not be applied to a large area or used continuously for a long time. Do not calcine it with fire. After calcining, it will decompose into arsenic trioxide, that is, arsenic, which is highly toxic.

This product mainly contains arsenic disulfide (As₂S₂) and a small amount of other heavy metal salts. Realgar water immersion agent (1:2) has varying degrees of inhibitory effects on a variety of skin fungi in vitro. Smoking with Acorus, Mugwort, and yellow mixture for more than 2 to 4 hours has a bactericidal effect on Staphylococcus aureus, Proteus, and Pseudomonas aeruginosa, as well as anti-schistosomiasis and malaria parasites.

Acute arsenic poisoning: usually occurs half an hour after taking the medicine, with symptoms such as dry throat, abdominal discomfort, pain, nausea, lack of strength, etc.; severe cases include severe vomiting, diarrhea, rice soup-like stools, decreased blood pressure, and oliguria or anuria. , unconsciousness, convulsion, difficulty breathing, and finally respiratory paralysis and death.

Traditional Chinese medicine can effectively treat dry eye syndrome, floaters, retinopathy, and various chronic eye diseases

1. Central nervous system: delirium, spasm, unconsciousness.
2. Peripheral nerves: 1 to 2 weeks to be decocted later, loss and weakening of half-body sensation, motor weakness, ascending paralysis, and sensitive limb pain.
3. Cardiovascular system: Palpitation, hypotension, myocarditis, atrioventricular conduction block, T Wave changes, QT segment prolongation and specific ventricular arrhythmia caused by Torsade de points.
4. Gastrointestinal system: nausea, vomiting, diarrhea, abdominal colicky pain, and in severe cases, death due to dehydration.
5. Hematology system: Most of the arsenic in blood (>95%) is combined with red blood cells; hemolytic anemia, thrombocytopenia, pancytopenia, agranular white blood cells, and dysplastic anemia.
6. Kidney: acute tubular necrosis, hematuria, renal cortical necrosis.
7. Liver: liver index increases, jaundice.
8. Skin: erythema, pruritus, pigmentation, keratinization, Mec's line on nails, ulceration, and chronic exposure can lead to skin cancer.
9. Other symptoms: fever, rhabdomyolysis, acute myositis, blackfoot.

Pathogenesis and poisoning mechanisms

Arsenic causes disease in the human body. It is generally believed that arsenic inhibits the enzyme activity of sulfhydryl (SH-) and affects the activity of enzymes in the respiratory chain, causing damage to cells and tissues. Arsenic generally exists in trivalent and pentavalent compounds, and trivalent arsenic is more toxic than pentavalent arsenic. Generally speaking, taking about 100mg of arsenic can cause clinical symptoms of poisoning, and exceeding 200mg can be fatal.

Rescue method (the following is the method of removing toxin recommended by general literature):

1. Acute arsenic poisoning is a potentially fatal emergency. Hypotension and arrhythmia are the main causes of death, so active treatment is required. Hypotension is usually caused by dehydration and requires large amounts of fluids. An electrocardiogram monitor can be used to monitor arrhythmias in the acute phase. In addition, attention should be paid to electrolyte balance, especially the concentrations of potassium, calcium and magnesium ions.
2. If acute oral administration occurs, seek medical attention immediately. Gastric lavage (gastric lavage with 0.05% potassium permanganate solution or 1% sodium sulfate solution) can be considered. Giving activated charcoal cannot significantly reduce the absorption of arsenic. If abdominal Magnesium suspension, mix equal amounts before use and shake well before use), take one spoonful every 5 to 10 minutes, stop taking the drug after vomiting, then use 50% magnesium sulfate solution 30ml for catharsis), pay attention to the balance of water and electrolytes question.
3. Use of chelating agents: For symptomatic patients or when the arsenic concentration in urine exceeds 200mg/l, it is generally recommended to start using chelating agents for metal poisoning. The following three drugs can be considered:
   1. Dimercaprol (BAL): Use dose of 3 to 5 mg/kg for intramuscular injection, once every 4 to 12 hours until symptoms are relieved, or another chelating agent is used, or the urine arsenic level When reduced to 50mg/24hrs.
   2. DMSA (succimer), a soluble BAL analog, is clinically more effective and less toxic. The initial dose is 10 mg/kg every 8 hours for 5 days, and then changed to every 12 hours for 14 days. A complete course of treatment. (This medicine is currently not available in Taiwan).
   3. D-Penicillamine can be used in acute or chronic arsenic poisoning. The oral dose is 100mg/kg/day, given in divided doses for 5 to 7 days.
4. Accelerate excretion: Patients with clinical renal failure may consider hemodialysis to improve renal failure. In addition, it may also help in the elimination of arsenic and dimercaprol conjugates.