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A native of Lintong, Shaanxi. His ancestral home is Baishui, Shaanxi Province. He was promoted to Yuan Dynasty in the 16th year of Wanli Dynasty (1588) and Jinshi in the following year. He successively served as the magistrate of Huoqiu County in Anhui Province and Jiangdu County in Jiangsu Province, in charge of merit examination of the Ministry of Civil Affairs, Shaoqing of Taichang Temple, deputy envoy of the Shandong Prosecution Department, chief officer of the Examination and Selection Department of the Ministry of Civil Affairs, and You Shaoqing of Dali Temple.

Wu paid attention to medicine in his early years and studied under Shu Wu Daichuan. In 1600, he was dismissed from his post for "disobeying the road" and became more interested in medicine. In the spring of 1606, the epidemic prevailed in the village. He used Guan's Bao Chi Complete Book treatment method and administered the medicine according to the prescription. In ten days, he lived nearly 100 years, which was highly praised by the villagers.

Wu wrote: Jiyin Gangmu 5 volumes (1620), Acne Series, Jiyang Gangmu 108 volumes (1626), There are also CiyouGangmu , Yizhi, Haifangshu, Jiuli Chapter, etc. . Wu is known as the "Hongru Confucian of Guanzhong". He loves poetry and literature and is praised for his knowledge and economics. There are two existing poems, Visiting Hot Springs and Climbing Lishan Mountain to See Tiger Spots, which are works praising the beautiful mountains and beautiful waters of Lintong.