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A native of Dongting, Dongting, Wu County (now Suzhou, Jiangsu), pestilence was popular many times in the Ming Dynasty, which was the objective motivation that promoted Wu's research on pestilence. At that time, the medical community "adhered to ancient methods but did not adapt to today's diseases" and "contracted ancient medicines based on today's diseases", which resulted in the ineffectiveness of medication. This strongly motivated his thinking. His strong sense of social responsibility made him determined to explore warm diseases. Pestilence is popular, "The teacher at that time mistakenly used the disease caused by cold to treat the disease, but never found that it was not in danger." Some people died due to the deficient stage of the disease, and some people died due to the misuse of Jun Tong and the disorder of attack and Tong. There were cases where doctors could not see him, and he used palliative medicine for acute illness, and died after delay. "It was everywhere", which made Wu so sad that he wrote Wenyi Lun in 1642.

The pestilence diseases contained in Wenyi Lun include diseases caused by cold, common cold, malaria, smallpox (chickenpox, smallpox), cholera, lump plague (glandular plague), shrimp, swollen-head infection, pestilential wind (leprosy), fire flow (erysipelas of shank), red eye swelling and pain (membraneitis, trachoma) ), yellow disease (hepatitis, jaundice), macula and papule, pharyngeal swelling, scabies treatment, etc. The content is extensive and is a summary of his personal experience with the prevalence of pestilence and clinical experience.

Wenyi Lun was a major breakthrough in the development of Chinese medicine, paving the way for the warm diseases school in the future. His innovative spirit was widely praised. Wu You-xing has actually come to the point of the theory of bacterial pathogenicity. His so-called hostility has quality, specificity, neutrality, and special pathogenicity. You only need to follow it to find out this A material ontology will make a historical breakthrough. Firstly, due to the limitations of the material and technical conditions at that time, and secondly, due to the influence of traditional ways of thinking, his successors have obviously regressed in this regard.

Wu's real record of disease caused by cold has been lost. There is also pestilence 合璧, which was compiled by Wang Jiamo in the Qing Dynasty on the basis of Wu's original work, with additions, deletions and additions.