This book is a comprehensive clinical medical work, later generations believe it was attributed to Hua Tuo of the Eastern Han Dynasty, but the exact date of its compilation remains undetermined.

The first half of the book belongs to the category of basic theory, while the second half focuses on clinical diagnosis and treatment (mainly internal medicine Zabing). The medical theory section consists of 49 chapters, connecting the generation and pathology of zang-fu organs to analyze symptoms and pulse manifestations, and discusses the deficiency and excess, cold and heat, and the methods of life and death Nishun of each zang-fu organ. The described diseases include cold reversal, overstrain injury, apoplexy hemiplegia, weak feet, edema, Bi disease, fullness syndrome, abdominal mass, etc. It also discusses common surgical conditions such as boils and sores, Yongju, etc. The book provides a relatively fair critique of the once-popular practice of "taking elixirs." The clinical section introduces various treatment formulas and the main diseases they treat. Most of the listed formulas have a strict combination of medicinals, with clear instructions on administration. Many formulas resemble classical formulas, and the discussion of formulas also contains profound meanings, highly valued by later clinical physicians.

The book's discussion on the differentiation of syndromes based on zang-fu organs had a significant influence on the later Yishui school.