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Compiled by Li Gao, it was written in 1529 AD. The author was fond of medicine when he was young and was very accomplished in medicine. His medical skills are specialized in treating diseases caused by cold, Yongju and eye diseases. He observed that most of the diseases suffered by the people were eating disorders and internal injuries caused by overwork. He put forward the argument that "internal injuries to the spleen and stomach lead to all diseases", and gradually formed an original systematic theory?? Piwei Lun theory, so later generations called him the representative of the "Butu Sect".

This series reflects these academic thoughts, and also compiles some famous doctors and classics from the Song, Jin and Yuan Dynasties, totaling 10 types. Song ? Cui Jia-yan wrote Maijue, 1 volume of Fanshu. Yuan? Zhu Zhen-heng wrote Jufang Fahui, 1 volume of Fanshu. Yuan? Li Gao wrote Piwei Lun, 3 volumes of Fanshu. Yuan? Zhu Zhen-heng wrote Gezhi Yulun, 1 volume of Fanshu. Yuan? Li Gao wrote Lanshi Micang, 3 volumes of Fanshu. Yuan? Li Gao wrote Neiwaishang Bianhuo Lun, 3 volumes of Fanshu. Yuan? Wang Hao-gu wrote Cishi Nanzhi, 2 volumes of Fanshu. Yuan? Wang Hao-gu wrote Tangye Bencao, 3 volumes of Fanshu. Yuan? Wang Lyu wrote Yijing Suhui Ji, 1 volume of Fanshu. Yuan? Qi De-zhi wrote Waike Jingyi, 2 volumes of Fanshu.

Dongyuan Shishu During the Wanli period of Ming Dynasty, two kinds of medical books Wang Hao-gu were added. Yuan? Wang Hao-gu wrote Yi Lei Yuan Rong, 1 volume of Fanshu. Yuan? Wang Hao-gu wrote Ban Lun Cui Ying, 1 volume of Fanshu. Dongyuan Shishu mainly reflects Li's long-term clinical practice and accumulated rich academic thoughts on the treatment of internal injuries and diseases. It had a great influence on later generations of doctors, and it still has practical and research value to this day.

The main existing editions are: the engraved edition in the 8th year of Jiajing reign of the Ming Dynasty; the engraved edition of Meinan Bookstore in the Jiajing period of the Ming Dynasty; the lithographic edition of the Shanghai Wensheng Bookstore in the 7th year of the reign of Emperor Guangxu of the Qing Dynasty (attached) The latter two); 1929 lithographed edition by Shanghai Mongolian Bookstore and Zhongyi Bookstore.