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This book is compiled by Li Chan. Published in the third year of Wanli (1575), there are more than 30 domestic and foreign editions, such as the first edition of Wanli, the edition of Yu Shengjiu of Shulin in the 30th year of Kangxi (1691), the corrected edition of Saoye Shanfang in 1931, and the edition printed by Shanghai Guangyi Book Company. The Japanese engraving in the third year of Genwa (1617), the engraving in the sixth year of Kanbun (1666), and the Murakami Heiji engraving in the fifth year of Enho (1677), etc. In 1988, Jiangsu Science and Technology Press published a proofread and annotated version.

The whole book is divided into internal and external collections. It says that "the doctor can know the internal and external portals, and then he can try to cure the disease, so as not to follow the monstrous prescriptions and waste people's lives. Therefore, it is called Yixue Rumen. A total of 9 Volume 1 contains brief medical treatises, medical biographies, meridian point illustrations, luck, maintenance, etc. Volume 1 is meridian and collateral, zang-fu organ, diagnostic method, acupuncture and moxibustion. Volume 2~. 3 refers to materia medica and six qi refers to diseases, medicines, and food treatments. Volumes 4 to 8 refer to internal and external medicine and first-aid prescriptions. It records the opinions of various schools and appends their own opinions. The end of the book is "Standards for Practicing Medicine", which discusses the requirements for medical practitioners to learn and cultivate medical ethics. It emphasizes that doctors should have a solid theoretical foundation and extensive professional knowledge, and should be loyal to their duties.