This book was compiled by Li Chan. It was published in the third year of the Wanli era (1575), and there are now over 30 editions published both domestically and internationally, such as the early Wanli edition, the 1691 edition by Yu Shengjiu of Shulin, the 1931 corrected edition by Saoye Shanfang, the edition printed by Shanghai Guangyi Book Company, the 1617 Japanese Genna edition, the 1666 Kanbun edition, the 1677 Enpo edition by Murakami Heiji, and others. In 1988, Jiangsu Science and Technology Publishing House published an annotated edition.

The book is divided into inner and outer collections, and the author states that "a physician who understands these inner and outer aspects can then devise methods to treat illnesses, avoiding the pitfalls of blindly following prescriptions and causing harm to patients, hence the title Yixue Rumen (Introduction to Medicine). It consists of 9 volumes. The first volume includes a brief introduction to medicine, biographies of physicians, diagrams and explanations of meridian points, as well as discussions on yunqi (five phases and six qi) and health preservation. Volume 1 covers meridians and collaterals, zang-fu organs, diagnostic methods, acupuncture, and moxibustion. Volumes 2 to 3 discuss materia medica, illnesses caused by six qi, medicinal treatments for diseases, and dietary therapy. Volumes 4 to 8 cover the diagnosis and treatment of internal, external, gynecological, and pediatric diseases, as well as emergency prescriptions.

The main text of the book is written in verse, supplemented by annotations that elaborate on the content. The annotations cite various scholars' opinions, along with the author's own views. At the end of the book is the "Guidelines for Medical Practice," which discusses the learning and ethical cultivation required for medical practitioners, emphasizing that physicians should have a solid theoretical foundation and extensive professional knowledge, and should be dedicated to their duties.