This book is also known as Zhenjiu Daquan, written by Yang Ji-zhou, and corrected by Jin Xian. It was published in the 29th year of the Wanli era (1601). It contains theories of acupuncture and moxibustion, treatments, and meridian and collateral back transport points, providing a preliminary summary of the main achievements of acupuncture and moxibustion before the Ming Dynasty. The book has over 50 editions to date. The commonly used edition is the 10-volume version, including the original edition, the Li Guiyue edition published in the Dingyou year of Shunzhi in the Qing Dynasty (1657), the 1963 typeset edition by the People's Medical Publishing House, and the 1984 annotated edition.

The entire book consists of 10 volumes. Volume 1 is the theoretical part, volumes 2-3 are songs and odes. Volume 4 includes diagrams of the supine and prone human body dimensions, Beishu, abdominal acupoints, measurement methods, discussions on nine needles, needle techniques, tonification and purgation, and acupuncture and moxibustion taboos; "Questions and Answers on the Flow of Meridians and Collaterals" is a summary of Yang's practical experience. Volume 5 covers the well, spring, stream, source, and sea points, midnight-noon ebb-flow acupuncture, and the eight acupoint techniques of the Ling Gui and Fei Teng. Volumes 6-7 discuss the five zang-organs, six fu-organs, and the indications of points on the fourteen meridians, meridian point songs, methods for verifying acupoints, extra meridians, collateral vessels, meridian sinews, key points, and extra points. Volume 8 begins with the great method of Shenying Jing, followed by discussions on the acupuncture and moxibustion treatments for 23 categories of diseases in internal, external, five sense organs, gynecology, and pediatrics. Volume 9 starts with a general discussion on treating symptoms and concludes with Yang's 31 medical cases. Volume 10 is an appendix, compiling Chen's (anonymous) Xiao Er An Mo Jing, making it the only surviving copy.